A family-of-seven have been dealt fresh tragedy after their home was ravaged by fire – their second house to be burned down in four months.

The out-of-control blaze engulfed the home in Alexandra Hills, east of Brisbane, about 11.30 pm on Tuesday, forcing the family to flee.

The home was burned to a blackened shell, but the single mother, her five children – including one in a wheelchair – and another adult escaped injury.