Three people were also injured in the fire in a two-storey house in Changshu city, media say.
Another three people were injured in the city of Changshu, north-west of Shanghai, Xinhua news agency says.
It says the fire – that started at about 04:30 local time (20:30 GMT Saturday) – has been put out.
It was not immediately known how many people lived in the building in Jiangsu province. An investigation into what caused the blaze is now under way.
Source: China house fire kills 22 in Jiangsu province – BBC News